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The Genomics Landscape
In the July 2021 issue of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., reflects on the legacy the LINCS program leaves as it has completed its goal of creating a large-scale, systematically generated molecular and cellular dataset.
… to analyze the consequences of perturbing agents (e.g., small molecules, genetic alterations, antibodies, and … 3 million profiles, with information about over 40,000 small molecules and genetic-perturbing agents, over 1,100 …
News Release
NHGRI will highlight rare disease research that benefits affected patients and provides insights into more common disorders on Rare Disease Day.
… hemodialysis," Dr. Gahl said. In Gaucher's disease, the small molecule NCGC607 chaperones mutated protein to the …
News Release
NHGRI awards $6.7 million in new research grants to develop DNA sequencing technologies that are more sensitive, faster, cheaper and more accurate.
… now have technology that uses light emitted from glowing molecules to figure out the correct order of a DNA sequence, … years Principal investigator: Stuart Lindsay, Ph.D. Two small business grants were awarded to the following: …
News Release
NHGRI researchers are studying the link between Parkinson's disease, and a rare disorder, Gaucher disease, by cross-breeding mice with the disease mutations.
… disease often have increased levels of alpha-synuclein, a small protein with a tendency to clump that can affect the …
15 Ways Genomics Influences Our World
Advances in genomics are reducing the cost of genome sequencing by a million-fold.
… " amplify " the DNA in the sample - that means they copy small parts of the sample to reach high enough levels for … step makes it possible to do DNA testing from very small starting amounts, like those in forensic samples or …
News Release
NIH awards more than $64 million to for a database of human cellular responses called the Library of Integrated Network-based Cellular Signatures or LINCS.
… behavior, in how cells respond to being exposed to various small molecules, genetic perturbations or genetic changes," said … and finding common responses to other known toxic molecules." A major challenge that will be addressed in the …
Staff
Dr. Pamela Schwartzberg is a adjunct investigator in NHGRI's Genetic Disease Research Branch.
… receptors (TCR) on T cells. Together with costimulatory molecules, these receptors initiate signal transduction … the Schwartzberg group has been studying T cell signaling molecules affected by primary immunodeficiencies, including … of cases of XLP are caused by mutations affecting a small adaptor molecule, SAP that binds to members of the SLAM …
Virtual Exhibit
The Human Genome Project changed traditional understandings of how and why scientific research is conducted. It was, however, not without its detractors. Early in 1990, there was an effort to stop funding for the nascent Human Genome Project, in the form of a letter writing campaign.
… and money. Today, it remains a fact that an incredibly small percentage of the genome, only 2%, actually codes for … entity. This is in contrast to what can be called “small science,” or inquiry driven by individual … investigators, which is done in smaller labs with a small staff led by a principal investigator. Historically, …
For Teachers
Lesson plan based on an award-winning DNA from the Beginning website, an animated primer on the basics of DNA, genes and heredity.
… concentrating on high school level activities under the Molecules of Genetics section of the DNA from the Beginning … problems, biographies and links. In addition to the Molecules of Genetics covered in this lesson, the website … study guide will be used to familiarize students with the Molecules of Genetics section of the DNA from the Beginning …
News Release
NHGRI researchers, collaborators at the University of California (UC) San Diego, UC Davis and the University of Pittsburgh School of Medicine lay out a new framework for comparing dog-to-human aging, one that uses epigenetics as a biological marker to better understand the aging process.
… epigenetic change called methylation, a process in which molecules called methyl groups are attached to particular DNA … long-lived breeds, a disproportionate number of which are small in size, versus breeds with a shorter lifespan, which …