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- Ethical, Legal and Social Implications (ELSI) Research Program3
- Genomics-Enabled Learning Health Systems (gLHS)2
- Genome Technology Program5
- Human Genome Reference Program (HGRP)1
- Impact of Genomic Variation on Function (IGVF) Consortium3
- Encyclopedia of DNA Elements (ENCODE) Project1
- Molecular Phenotypes of Null Alleles in Cells (MorPhiC)1
- NHGRI Genomic Data Science Analysis, Visualization and Informatics Lab-space (AnVIL)3
- Genomics Research to Elucidate the Genetics of Rare Diseases (GREGOR) Consortium2
- Developmental Genotype-Tissue Expression (dGTEx)1
- Multi-Omics for Health and Disease (Multi-Omics)1
News Release
NIH researchers have developed and released an innovative software tool, called Verso, to assemble truly complete (i.e., gapless) genome sequences from a variety of species. The software makes the process of assembling complete genome sequences more affordable and accessible.
… Software opens the door for a greater number of complete genome sequences. … National Institutes of Health researchers … Verkko grew from assembling the first gapless human genome sequence , which was finished last year by the … software quickly and precisely assembled the sequences of whole chromosomes, which was once a painstaking feat. As …
Educational Resources
An anticodon is a trinucleotide sequence complementary to that of a corresponding codon in a messenger RNA (mRNA) sequence.
… Anticodon … An anticodon is a trinucleotide sequence complementary to that of a corresponding codon in a messenger RNA (mRNA) sequence. … Codon, DNA, Transfer RNA, TRNA, Messenger RNA, MRNA, Complementary Sequence … A codon is a DNA or RNA sequence of three …
The Genomics Landscape
In the October 2024 issue of The Genomics Landscape, NHGRI Director Eric Green welcomes James Thomas as the new director for NIH Intramural Sequencing Center (NISC).
… to discuss the many challenges of sustaining critical data resources needed for life science and biomedical … website . Applications close in January.  All the best, … Genome-wide detection of somatic mosaicism at short tandem … repeats. The researchers applied the tool to study 460 whole-genome sequences, revealing hundreds of mosaic short …
Educational Resources
A contig is a series of overlapping DNA sequences used to make a map that reconstructs the original DNA sequence of a chromosome or a region of a chromosome.
… used to make a map that reconstructs the original DNA sequence of a chromosome or a region of a chromosome. … DNA … of cloned segments of DNA across a genomic region, while a sequence contig provides the actual DNA sequence of a genomic region. … A contig is a series of …
Profile
Jim Mullikin pioneered DNA sequencing technologies during the Human Genome Project and other major advances in genomics.
… pioneered DNA sequencing technologies during the Human Genome Project and other major advances in genomics. … Anna … Human Genome Project in 1997, and the draft human genome sequence was finished just before I moved to NHGRI in 2003. Seeing the whole progress, from the very early days of Sanger sequencing …
News Release
NHGRI will provide approximately $5.8 million over five years to create an educational hub for computational genomics and data science. The hub will provide new educational and research opportunities for students of diverse backgrounds, including those from groups historically underrepresented in the biomedical sciences.
… Funding to enhance diversity in genomic data science through cloud computing. … National Institutes … create an educational hub for computational genomics and data science. The hub will provide new educational and … Office of Genomic Data Science within the National Human Genome Research Institute (NHGRI). “Instead of requiring …
Research Funding
A collaborative large-scale genome sequencing effort to identify rare risk and protective variants contributing to multiple common disease phenotypes.
… Disease Genomics (CCDG) are a collaborative large-scale genome sequencing effort to comprehensively identify rare … NHLBI. We currently estimate that the CCDG program will sequence approximately 100K whole genomes and 125K whole exomes during the life of the …
Fact Sheets
Comparative genomics is a field of biological research in which researchers compare the complete genome sequences of different species.
… researchers use a variety of tools to compare the complete genome sequences of different species. By carefully comparing … protein is produced by any given gene is determined by the sequence in which four building blocks - adenine (A), thymine … NHGRI has sequenced many varieties, providing critical data for understanding genetic variation. DNA sequencing …
News Release
New grants totaling approximately $29.5 million will enable scientists to generate and maintain the most comprehensive reference sequence of the human genome.
… to generate and maintain the most comprehensive reference sequence of the human genome. The awards, made over five years pending the … research studies that use or analyze human genomic data rely on the established reference sequence of the human …
Research Funding
The Encyclopedia of DNA Elements (ENCODE) Pilot Project launched in September 2003 to identify all functional elements in the human genome sequence.
… The National Human Genome Research Institute (NHGRI) launched a public research … to identify all functional elements in the human genome sequence. … In April 2003, the finished sequence of the human … sequences from other vertebrate genomes, identified from whole genome shotgun assemblies or obtained by direct …