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News Release
Scientists are using an exciting gene editing tool called CRISPR/Cas9 to protect plants from harmful DNA viruses, strengthening the plant's protections.
… Scientists are using an exciting gene editing tool called CRISPR/Cas9 to protect plants from harmful DNA viruses. The CRISPR/Cas9 system has previously been adapted for use in …
News Release
A new method of targeting specific DNA sequences in zebrafish could accelerate the discovery of gene function and the identification of disease genes in humans.
… reported that the gene-editing technology known as CRISPR/Cas9 is six times more effective than other techniques at … specific sequences. The study also demonstrated that the CRISPR/Cas9 method can be used in a "multiplexed" fashion - …
Policy Issues
Scientific institutions are developing recommendations to support the responsible use of human gene-editing research.
… editing, the scientific background of gene editing and CRISPR in particular, the clinical applications of gene … Among the protocols was one that proposed the use of CRISPR to edit the T cells (a type of immune cell) of … create multiple, simultaneous gene knockouts using CRISPR/Cas9 in zebrafish (Varshney, et al., 2015). The lab has also …
Staff
Lisa Garrett is an associate investigator and director of the NHGRI Transgenic Mouse Core.
… includes maintaining an updated guide for protocols using CRISPR/Cas9 and other gene-editing tools. This guide is provided on … more recently gene editing using site-specific nucleases (CRISPR/Cas9). The core breeds, in-house, 90 percent of the …
Staff
Dr. Raman Sood is an associate investigator in the Translational and Functional Genomics Branch and director of the Zebrafish Core at the National Human Genome Research Institute.
… mutagenesis using genome editing nucleases, particularly CRISPR/Cas9 to generate single or multiple gene knockout mutants in … generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes . DNA Repair 107: 103173. …
Policy Issues
Patients with genetic disorders and members of the public have diverse about germline genome editing.
… "compelling medical applications justifying the use of CRISPR/Cas9 in embryos." 3 In July 2017, using non-federal funding, … Huang and Sun Yat-sen of University in Guangzhou used CRISPR on nonviable embryos from local fertility clinics in …
News Release
DNA Day Reddit “Ask Me Anything” prompts rousing discussion.
… found? Last but not least, why should we even do it? The CRISPR/Cas9 gene editing system allows scientists to modify DNA at specific locations. Dr. Katz: In terms of using CRISPR to modify an embryo resulting in a live birth, the …
Staff
William J. Pavan, Ph.D. is the chief of NHGRI's Genetic Disease Research Branch.
… to human pigmentation. Future studies involve using CRISPR/Cas9 techniques to generate a series of pheomelanin-related …
File
… 2017 - 2018. 6. Deniz E (PI). Genome -Wide Screening With CRISPR/Cas9 and Modelling of Resistance Mechanims Developed Against …
File
… , Talim B, Dincer PR. Evaluation of Phenotypic Effects of CRISPR/Cas9 Mediated LRP5 Variations on Zebrafish. 2020. (TUBITAK … Talim B, Dincer PR. Evaluation of Phenotypic Effects of CRISPR/Cas9 Mediated CHST6 Knock -Out on Zebrafish Cornea. …