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- Genome Technology Program2
- Impact of Genomic Variation on Function (IGVF) Consortium3
- Molecular Phenotypes of Null Alleles in Cells (MorPhiC)1
- NHGRI Genomic Data Science Analysis, Visualization and Informatics Lab-space (AnVIL)1
- Genomics Research to Elucidate the Genetics of Rare Diseases (GREGOR) Consortium1
- Developmental Genotype-Tissue Expression (dGTEx)1
News Release
A new study by scientists at NHGRI, suggests that iPSCs do not develop more mutations than cells that are duplicated by subcloning.
… any adult cell to its earliest stage of development (a pluripotent stem cell) and change it into different types of cells in the body. … Called induced pluripotent stem cells (iPSCs), this technique opens …
Educational Resources
A stem cell is a cell with the potential to form many of the different cell types found in the body.
… Stem Cell … A stem cell is a cell with the potential to form many of the … of the different cell types found in the body. When stem cells divide, they can form more stem cells or other cells that perform specialized functions. …
Staff
Dr. Manfred Boehm is a an adjunct investigator for the Office of the Clinical Director at NHGRI.
… boards of Trends in Cardiovascular Medicine , ISRN Stem Cells , Atherosclerosis , and Journal of Molecular … Boehm, human vascular diseases, precision medicine, human induced pluripotent stem cells (hiPSCs), arterial calcification … Dr. …
News Release
In a study published in the journal Science, collaborators at NHGRI, the National University of Ireland, Galway, and the Whitney Laboratory for Marine Bioscience at the University of Florida, Augustine, reported that activation of the gene Tfap2 in adult stem cells in Hydractinia can turn those cells into germ cells in a cycle that can repeat endlessly.
… called Hydractinia, does so because it produces germ cells, which are precursors to eggs and sperm, nonstop … reported that activation of the gene Tfap2 in adult stem cells in Hydractinia can turn those cells into germ … for the specific gene or genes that tell Hydractinia’ s stem cells to become germ cells,” said Dr. Baxevanis. The …
Educational Resources
A somatic cell is any cell of the body except sperm and egg cells.
… Somatic Cells … A somatic cell is any cell of the body except sperm and egg cells. … Cell, Chromosome, Diploid, Mutation, Germ Line … Somatic cells are the cells in the body other than sperm and egg …
Educational Resources
A cell cycle is a series of events that takes place in a cell as it grows and divides.
… mitosis, and completes its division. The resulting cells, known as daughter cells, each enter their own interphase and begin a new round …
News Release
Scientists set their sights on chromatin - the DNA-protein complex that packages DNA into chromosomes in the cell - to better understand how the genome works.
… its make-up is different among cell types, even among cells that are similar. Investigators from two National Human … what to do - among three types of cells: mouse embryonic stem (ES) cells, embryonic fibroblasts and hematopoietic … subtypes based on chromatin make-up. They found that each stem cell subtype had a different ability to develop into …
Genetic Disorders
Sickle cell disease is a group of inherited red blood cells disorders.
… from the lungs to other parts of the body. Red blood cells with normal hemoglobin (hemoglobin-A) are smooth and … rod-like structures. These structures cause red blood cells to become stiff, assuming a sickle shape. Their shape causes these red blood cells to pile up, causing blockages and damaging vital organs …
Educational Resources
The cell membrane, also called the plasma membrane, is found in all cells and separates the interior of the cell from the outside environment.
… membrane, also called the plasma membrane, is found in all cells and separates the interior of the cell from the outside … … Plasma Membrane, Proteins, Glycoproteins, Lipid Bilayer, Cells … The cell membrane, also called the plasma membrane, is found in all cells and separates the interior of the cell from the outside …
Media Availability
TCGA researchers have found that chromophobe renal cell carcinoma stems partly from gene alterations in the mitochondria, the cell's energy supplier.