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- Ethical, Legal and Social Implications (ELSI) Research Program1
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Educational Resources
An animal model is a non-human species used in medical research because it can mimic aspects of a disease found in humans.
… Animal Model … An animal model is a non-human species used in medical research because it can mimic aspects of a disease found in humans. … Biomedical Research, Ethics, … of a biological process or disease found in humans. Animal models (e.g., mice, rats, zebrafish and others) are …
News Release
NIH researchers compared a new genetic animal model of Down syndrome to the standard model and found the updated version to be enhanced.
… options for Down syndrome. … National Institutes of Health researchers compared a new genetic animal model of Down syndrome to the standard model and found … Scientists often use different strains of mice as animal models to study human diseases because most genes in humans …
News Release
NHGRI researchers are studying the link between Parkinson's disease, and a rare disorder, Gaucher disease, by cross-breeding mice with the disease mutations.
… the puzzling link between a common disorder, Parkinson's disease, and a rare disorder, Gaucher disease, by … cross-breeding mice to carry human mutations causing each of the two diseases. They published their findings in the … mutations. ​ … Gaucher disease, Parkinson's disease, mouse models, GBA1, alpha-synuclein, Ellen Sidransky, M.D., Nahid …
Research at NHGRI
The NHGRI Office of Laboratory Animal Medicine promotes the humane care and use of animals in biomedical and behavioral research, teaching, and testing.
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… The National Human Genome Research Institute (NHGRI) Office of Laboratory Animal Medicine (OLAM) promotes the humane care and use of … research animals and for enhancing their well-being. The animal program and animal laboratory areas are inspected and …
Educational Resources
A mouse model is a laboratory mouse used to study some aspect of human physiology or disease.
… model is a laboratory mouse used to study some aspect of human physiology or disease. … Mouse Model, Knockout Mouse, Genetic Engineering, … from many of the same diseases. A large number of mouse models have been created to target specific human diseases …
News Release
Researchers build a statistical model using family health history to improve disease risk assessment
Researchers at the National Human Genome Research Institute (NHGRI) have developed a new statistical model that can predict the risk for developing diseases by combining information about family member health and lifestyle factors from family members.
… The researchers used type 2 diabetes mellitus (T2D) as the disease model for their study. An estimated 30 million people in the US suffer from the condition, making it one of the most common and costly chronic diseases to treat. T2D … history information are piecemeal and specific, relying on models that can only be used for complex diseases such as …
Educational Resource
A step-by-step printable guide for folding a transfer RNA (tRNA) paper model.
… called tRNAs for short, play a key role in the creation of new proteins, known as translation. The tRNAs serve as … the growing protein molecule. The mRNA is read out in sets of three letters called codons, and each codon corresponds to … common start codon. Adapted from PDB-101: Learn: Paper Models: tRNA [rcsb.org] For more information on tRNA see …
Talking Glossary
Un modelo animal es una especie no humana que se usa en investigaciones biomédicas porque puede replicar algunos aspectos de un proceso biológico o de una enfermedad presentes en los seres humanos.
… Modelo animal … Un modelo animal es una especie no humana que se usa … used in biomedical research because it can mimic aspects of a biological process or disease found in humans. Animal models (e.g., mice, rats, zebrafish and others) are …
News Release
A team from the NIH has surmounted a major obstacle to testing potential drug therapies for a rare, genetic condition called Gaucher disease.
… Raymond MacDougall … A team from the National Institutes of Health has surmounted a major obstacle to testing … therapies for a rare, genetic condition called Gaucher disease. Researchers from the National Human Genome Research … most common, age-related dementia. "These new cellular models of Gaucher disease are helping to better explain the …
News Release
UDN expands the footprint of the network with a new metabolomics core and increased model organism capabilities.
… Jeannine Mjoseth … The National Institutes of Health (NIH) has awarded 16 four-year grants to academic … and medical centers nationwide to begin the second phase of the Undiagnosed Diseases Network (UDN). The total … to use that knowledge to reduce the burden of neurological disease. About the National Institutes of Health (NIH): NIH, …