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- Genetic Architecture of Complex Traits1
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- Genomics Research to Elucidate the Genetics of Rare Diseases (GREGOR) Consortium2
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Educational Resources
A complex disease is caused by the interaction of multiple genes and environmental factors.
… Complex Disease … A complex disease is caused by the interaction of multiple … physical and social environment. For this reason, complex diseases are also called multifactorial diseases. This stands in contrast to a “simple” genetic …
Event
On November 16-17, 2023, the National Human Genome Institute will co-sponsor a workshop, Advances in the Genetic Architecture of Complex Human Traits, to take a historically grounded and forward-looking approach towards dissecting the genetic architecture of complex traits in humans.
… including societal and structural factors, influencing diseases and traits? What does this mean for understanding … organization? It is generally believed that less complex traits or “intermediate phenotypes” have simpler … Yet, even low-level molecular traits may have surprisingly complex architectures. Do we have the necessary theoretical …
Research at NHGRI
The Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch studies the genomic and social determinants of complex diseases.
… (MCIDGB) studies the genomic and social determinants of complex diseases. … Investigators focus, in particular, on diseases … that explore the patterns and determinants of common, complex diseases in populations in the United States and …
Event
On May 1–2, 2018, the National Human Genome Research Institute (NHGRI) sponsored this NHGRI workshop in Silver Spring, Maryland.
… the NHGRI workshop, Revisiting the Missing Heritability of Complex Diseases, Ten Years On , in Silver Spring, Maryland, on May … 8777 Georgia Ave … Revisiting the Missing Heritability of Complex Diseases, Ten Years On … NHGRI sponsored the …
Staff
Dr. Neil Hanchard is a clinical investigator within the Center for Precision Health Research (CPHR) and head of the Childhood Complex Disease Genomics Section within the CPHR.
… small effects) or is more consistent with rare Mendelian diseases that are more striking in childhood (single genes … and natural selection in the Major Histocompatibility Complex. After returning to Jamaica to study sickle cell … and Human genetics at BCM, focusing on the genetics of complex childhood diseases in diverse populations. In …
News Release
NHGRI has appointed Neil Hanchard, M.D., Ph.D., as a clinical investigator within the Medical Genomics and Metabolic Genetics Branch (MGMGB) in the Division of Intramural Research. Dr. Hanchard will head the Childhood Complex Disease Genomics Section within the MGMGB.
… Ganguly, Ph.D. … Dr. Hanchard will lead the new Childhood Complex Disease Genomics Section. … The National Human Genome … Intramural Research. Dr. Hanchard will head the Childhood Complex Disease Genomics Section within the MGMGB. “We are … genomic and genetic tools to understand complex pediatric diseases and traits in diverse populations. His efforts will …
News Release
NHGRI will highlight rare disease research that benefits affected patients and provides insights into more common disorders on Rare Disease Day.
… that is part of a global effort to raise awareness of rare diseases. Several NHGRI staff members - Anastasia L. Wise, … studies have the potential to shed light on more common diseases in a perspective published February 22, 2017, in the … clinical director and director of the NIH Undiagnosed Diseases Program (UDP), offered other examples of rare …
For Patients and Families
A rare disease is generally considered to be a disease that affects fewer than 200,000 people in the United States at any given time.
… States at any given time. There are more than 6,800 rare diseases. Altogether, rare diseases affect an estimated 25 million to 30 million Americans. … There are more than 6,800 rare diseases. Altogether, rare diseases affect an estimated 25 …
Research Funding
Building upon a foundation of quantitative genetics laid over a century ago, applying modern genomic approaches to resolve how genetic and non-genetic factors shape variation in human diseases and traits.
… application of genetic findings, especially for the most complex human traits. Fortunately, the growing availability … … To support research into the genetic architecture of complex human traits through investigator-initiated projects, … now being applied towards illuminating contemporary human diseases and traits. This webinar will seek input from the …
15 Ways Genomics Influences Our World
Genomics is ending diagnostic odysseys for patients with rare diseases.
… is ending diagnostic odysseys for patients with rare diseases. … Did you know that there are truly rare people … of these patient groups are accelerating research on rare diseases by recruiting patients with the same condition to … the mutations in the PRNP gene that cause prion diseases like FFI . Along with their colleagues, the couple …