2003

2011

2020

• Maintain an overarching focus on using genomics to understand biology, to enhance knowledge about disease, and to improve human health
• Sustaining and improving a robust foundation for genomics
• Maximize the usability of genomics for all members of the public, including the ability to access genomics in healthcare

• Champion a diverse genomics workforce
• Provide a conceptual research framing that consistently examines the role of both genomic and non-genomic contributors to health and disease
• Promote robust and consistently applied standards in genomics research

• Embrace the interdisciplinary and team-oriented nature of genomics research
• Adhere to the highest expectations and requirements related to open science, responsible data sharing, and rigor and reproducibility in genomics research
• Pursue advances in genomics as part of a vibrant global community of genomics researchers and funders

• Genome structure and function
• Enable the routine generation and analysis of increasingly complex genomic data
• Use evolutionary and comparative genomic data to maximize understanding of genome function

• Genomic data science
• Develop new methods and build sustainable data resources for genomics research
• Ensure facile storing, sharing, and computing on large genomic datasets
• Develop integrated knowledgebases and informatics methods for genomic medicine

• Genomics and society
• Understand the interrelationships between genomics and the social and environmental factors that influence human health
• Empower people to make well-informed decisions about genomic data and develop data-stewardship systems that reinforce their choices
• Increase the genomic literacy of all sectors of society

• Training and genomics workforce development
• Ensure that the next generation of genomic scientists are sufficiently trained in data science
• Train healthcare providers to integrate genomics into the clinical workflow
• Foster a diverse genomics workforce

• Laboratory and computational technologies
• Transform the study of the functional consequences of genomic variation by enhancing the scale of DNA synthesis and editing
• Maximally leverage the usability and utility of emerging datasets for genomic studies of human health and disease

• Biological insights
• Establish the means to determine the functional consequences of genomic variants affecting human health and disease
• Characterize intraindividual genomic variation and understand its role in human disease

• Implementation science
• Develop and assess strategies for implementing the use of genomic information in clinical care
• Test public health approaches for implementing population-wide genomic screening

• Acquire an increasingly comprehensive view of the roles and relationships of genes and regulatory elements in pathways and networks
• Determine the genetic architecture of most human diseases and traits
• Design studies that include diverse ancestral populations to enable scientific discoveries and genomic medicine for all

• Understand how the use of genomics can influence concepts of health, disease, responsibility, identity, family, and community
• Extend multi-omic studies of human disease and health into clinical settings
• Design and use genomic learning healthcare systems for knowledge generation and improvements in clinical care