Mike Pazin, Ph.D.
Program Director
Division of Genome Sciences
Education
Ph.D. University of California, San Francisco
B.S. Massachusetts Institute of Technology
Last updated: October 1, 2024
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Division of Genome Sciences
Ph.D. University of California, San Francisco
B.S. Massachusetts Institute of Technology
Dr. Pazin joined the National Human Genome Research Institute's NHGRI's Extramural Research Program in 2011. Mike is part of the NHGRI team overseeing the IGVF Consortium, developing a framework for systematically understanding the effects of genomic variation on genome function and how these effects shape phenotypes. Mike is one of the working group coordinators for the 4D Nucleome (4DN) program. He manages a portfolio of grants in functional genomics, variant characterization, epigenomics and nuclear architecture. He has worked on the NHGRI Data Access Committee, the ENCODE project, Common Fund Epigenomics modENCODE, the Non-Coding Variants (NoVa) program, and the Genomics of Gene Regulation (GGR)
Prior to joining NHGRI, Dr. Pazin was a principal investigator conducting research on the role of chromatin remodeling in gene regulation, at Massachusetts General Hospital/Harvard Medical School and the National Institute on Aging. This research was performed using cell-free (biochemical) assays and cell-based (single-gene and genomic) assays using T helper cells and neurons as model systems. He received his B.S. in chemistry from MIT in Cambridge, Massachusetts, his Ph.D. in cell biology from University of California, San Francisco (UCSF), and completed postdoctoral training at University of California, San Diego (UCSD).
Roy AL, Conroy RS, Taylor VG, Mietz J, Fingerman IM, Pazin MJ, Smith P, Hutter CM, Singer DS, Wilder EL. Elucidating the structure and function of the nucleus-The NIH Common Fund 4D Nucleome program. Mol Cell. 2023 Feb 2;83(3):335-342. doi: 10.1016/j.molcel.2022.12.025. Epub 2023 Jan 13. [PubMed]
Perspectives on ENCODE. ENCODE Project Consortium, Snyder MP, Gingeras TR, Moore JE, Weng Z, Gerstein MB, Ren B, Hardison RC, Stamatoyannopoulos JA, Graveley BR, Feingold EA, Pazin MJ, Pagan M, Gilchrist DA, Hitz BC, Cherry JM, Bernstein BE, Mendenhall EM, Zerbino DR, Frankish A, Flicek P, Myers RM. Nature. 2020 Jul;583(7818):693-698. doi: 10.1038/s41586-020-2449-8. Epub 2020 Jul 29. [PubMed]
Using the ENCODE Resource for Functional Annotation of Genetic Variants. Pazin MJ. Cold Spring Harb Protoc. 2015 Mar 11;2015(6):522-36. doi: 10.1101/pdb.top084988. PMID: 25762420
An integrated encyclopedia of DNA elements in the human genome. ENCODE Project Consortium. Nature. 2012 Sep 6;489(7414):57-74. doi: 10.1038/nature11247. PMID: 22955616
ATP-dependent chromatin remodeling in T cells. Wurster AL, Pazin MJ. Biochem Cell Biol. 2012 Feb;90(1):1-13. doi: 10.1139/o11-042. Epub 2011 Oct 14. PMID: 21999456
CHD5, a brain-specific paralog of Mi2 chromatin remodeling enzymes, regulates expression of neuronal genes. Potts RC, Zhang P, Wurster AL, Precht P, Mughal MR, Wood WH 3rd, Zhang Y, Becker KG, Mattson MP, Pazin MJ. PLoS One. 2011;6(9):e24515. doi: 10.1371/journal.pone.0024515. Epub 2011 Sep 13. PMID: 21931736
IL-10 transcription is negatively regulated by BAF180, a component of the SWI/SNF chromatin remodeling enzyme. Wurster AL, Precht P, Becker KG, Wood WH 3rd, Zhang Y, Wang Z, Pazin MJ. BMC Immunol. 2012 Feb 15;13:9. doi: 10.1186/1471-2172-13-9. PMID: 22336179
NF-κB and BRG1 bind a distal regulatory element in the IL-3/GM-CSF locus. Wurster AL, Precht P, Pazin MJ. Mol Immunol. 2011 Sep;48(15-16):2178-88. doi: 10.1016/j.molimm.2011.07.016. Epub 2011 Aug 9. PMID: 21831442
Dynamic BRG1 recruitment during T helper differentiation and activation reveals distal regulatory elements. De S, Wurster AL, Precht P, Wood WH 3rd, Becker KG, Pazin MJ. Mol Cell Biol. 2011 Apr;31(7):1512-27. doi: 10.1128/MCB.00920-10. Epub 2011 Jan 24. PMID: 21262765
The SNF2H chromatin remodeling enzyme has opposing effects on cytokine gene expression. Precht P, Wurster AL, Pazin MJ. Mol Immunol. 2010 Jul;47(11-12):2038-46. doi: 10.1016/j.molimm.2010.04.009. Epub 2010 May 15. PMID: 20471682
Mi2beta shows chromatin enzyme specificity by erasing a DNase I-hypersensitive site established by ACF. Ishii H, Du H, Zhang Z, Henderson A, Sen R, Pazin MJ. J Biol Chem. 2009 Mar 20;284(12):7533-41. doi: 10.1074/jbc.M807617200. Epub 2009 Jan 21. PMID: 19158090
BRG1-mediated chromatin remodeling regulates differentiation and gene expression of T helper cells. Wurster AL, Pazin MJ. Mol Cell Biol. 2008 Dec;28(24):7274-85. doi: 10.1128/MCB.00835-08. Epub 2008 Oct 13. PMID: 18852284
Nucleosome mobility and the maintenance of nucleosome positioning. Pazin MJ, Bhargava P, Geiduschek EP, Kadonaga JT. Science. 1997 May 2;276(5313):809-12. doi: 10.1126/science.276.5313.809. PMID: 9115208
SWI2/SNF2 and related proteins: ATP-driven motors that disrupt protein-DNA interactions? Pazin MJ, Kadonaga JT. Cell. 1997 Mar 21;88(6):737-40. doi: 10.1016/s0092-8674(00)81918-2. PMID: 9118215
NF-kappa B-mediated chromatin reconfiguration and transcriptional activation of the HIV-1 enhancer in vitro. Pazin MJ, Sheridan PL, Cannon K, Cao Z, Keck JG, Kadonaga JT, Jones KA. Genes Dev. 1996 Jan 1;10(1):37-49. doi: 10.1101/gad.10.1.37. PMID: 8557193
ATP-dependent nucleosome reconfiguration and transcriptional activation from preassembled chromatin templates. Pazin MJ, Kamakaka RT, Kadonaga JT. Science. 1994 Dec 23;266(5193):2007-11. doi: 10.1126/science.7801129. PMID: 7801129
Last updated: October 1, 2024