Revisiting the Missing Heritability of Complex Diseases, Ten Years On
Event Details
The National Human Genome Research Institute (NHGRI) sponsored the NHGRI workshop, Revisiting the Missing Heritability of Complex Diseases, Ten Years On, in Silver Spring, Maryland, on May 1–2, 2018. The goals of the workshop were to discuss what was has been learned since 2008, explore the value of identifying sources of missing heritability, and identify research that should be pursued to determine these sources.
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Sheraton Silver Spring
Agenda
Executive Summary
Meeting Summary
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Tuesday, May 2, 2018
- 8:30 a.m Welcome, Introductions
Peter Visscher
Teri Manolio - 8:45 a.m. Workshop rationale and objectives
Teri Manolio
Peter Visscher - 9:00 a.m. Impact of missing heritability publication in Nature
Orli Bahcall
Slides (PDF)
Slides (PowerPoint) - 9:10 a.m. Missing heritability circa 2009
Teri Manolio
Slides (PDF)
Slides (PowerPoint) - 9:30 a.m. Quantifying the genetic architecture and heritability of complex traits: estimation and prediction
Peter Visscher
Slides (PDF)
Slides (PowerPoint) - 9:50 a.m. Discussion
Teri Manolio - 10:50 a.m. Quantifying (missing) heritability for common disease from GWAS data
Naomi Wray
Slides (PDF)
Slides (PowerPoint) - 11:10 a.m. Rare Variants
David Goldstein
Slides (PDF)
Slides (PowerPoint) - 11:30 a.m. Monogenic contributions to complex traits
Judy Cho
Slides (PDF)
Slides (PowerPoint) - 11:50 a.m. Discussion
Peter Visscher - 1:20 p.m. Structural and multi-alleic variation
Steve McCarroll
Slides (PDF)
Slides (PowerPoint) - 1:40 p.m. Omnigenic architecture of human complex traits
Jonathan Pritchard
Slides (PDF)
Slides (PowerPoint) - 2:00 p.m. Epigenetic effects and gene expression
Alexis Battle
Slides (PDF)
Slides (PowerPoint) - 2:20 p.m. Discussion
Lon Cardon - 3:20 p.m. How sex-specific, environment-specific and genetic background-specific effects generate missing heritability
Trudy Mackay
Slides (PDF)
Slides (PowerPoint) - 3:40 p.m. Gene-environment interaction
David Hunter
Slides (PDF)
Slides (PowerPoint) - 4:00 p.m. Selection effects on complex trait architecture
Guy Sella
Slides (PDF)
Slides (PowerPoint) - 4:20 p.m. Discussion
Erin Ramos - 4:50 p.m. Family Studies
Lynn Jorde
Slides (PDF)
Slides (PowerPoint) - 5:10 p.m. Better phenotyping and use of biomarkers
David Valle
Slides (PDF)
Slides (PowerPoint) - 5:30 p.m. Discussion
Greg Gibson
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Wednesday, May 2, 2018
- 8:30 a.m. Mind the (diversity) gap: Contributions of diverse populations to common disease studies
Lucia Hindorff
Slides(PDF)
Slides(PowerPoint) - 8:50 a.m. Missing heritability: Contributions from genomic studies in African ancestry populations
Charles Rotimi
Slides(PDF)
Slides(PowerPoint) - 9:10 a.m. Contribution of diverse populations and expanded catalogues of human variation to our understanding of low frequency and rare variants
Eimear Kenny
Slides(PDF)
Slides(PowerPoint) - 9:30 a.m. Discussion
David Hunter - 10:30 a.m. Missing epistasis
Andy Clark
Slides(PDF)
Slides(PowerPoint) - 10:50 a.m. Impact of indirect genetic effects on effect estimages, heritability estimates and missing heritability
Augie Kong
Slides(PDF) - 11:10 a.m. Discussion
Lynn Jorde - 11:40 a.m. Lessons learned and next steps
Teri Manolio
Peter Visscher
All
Slides (PDF)
Slides (PowerPoint)
Last updated: May 1, 2018