Ayo P. Doumatey, Ph.D.
Center for Research on Genomics and Global Health
B.S. Université Claude Bernard
M.S. Université Claude Bernard
Ph.D. Howard University
Biography
Dr. Doumatey is currently a Staff Scientist at the Center for Research on Genomics and Global Health (CRGGH), part of National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH).
Dr. Doumatey received her Bachelor’s and Master’s from the Department of Biochemistry, at the University Claude Bernard, Lyon, France with interests in Microbiology and Cellular and Molecular Endocrinology. During and after her Master’s, she trained and acquired several technical skills across different industries mainly research institution (INSERM, Lyon), clinical and medical laboratory, and vaccine production (Institute Pasteur-Merieux- Connaught, Marcy-l ’Etoile). After completing a graduate certificate in quality assurance and quality control at the school of pharmacy, University Claude Bernard, Lyon, France in 1999, she relocated in Washington D.C. area where she received her PhD in Medical Microbiology from Howard University.
She has conducted research on genetic epidemiology of metabolic disorders especially obesity and obesity-related traits in populations of African ancestry. One of her research interests is to understand the involvement of inflammatory markers/ adipokines and lipids in the development of obesity co-morbidities. She has used different strategies to study the complex molecular basis of metabolic disorders including adipokine profiling, whole genome gene expression profiling, genome-wide association studies, proteomics, and whole exome sequencing (WES). She has authored, and co-authored numerous research manuscripts and I has recently developed interest in a subtype of obesity: the metabolically healthy obesity (MHO) and microbiome in health and diseases.
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Biography
Dr. Doumatey is currently a Staff Scientist at the Center for Research on Genomics and Global Health (CRGGH), part of National Human Genome Research Institute (NHGRI), National Institutes of Health (NIH).
Dr. Doumatey received her Bachelor’s and Master’s from the Department of Biochemistry, at the University Claude Bernard, Lyon, France with interests in Microbiology and Cellular and Molecular Endocrinology. During and after her Master’s, she trained and acquired several technical skills across different industries mainly research institution (INSERM, Lyon), clinical and medical laboratory, and vaccine production (Institute Pasteur-Merieux- Connaught, Marcy-l ’Etoile). After completing a graduate certificate in quality assurance and quality control at the school of pharmacy, University Claude Bernard, Lyon, France in 1999, she relocated in Washington D.C. area where she received her PhD in Medical Microbiology from Howard University.
She has conducted research on genetic epidemiology of metabolic disorders especially obesity and obesity-related traits in populations of African ancestry. One of her research interests is to understand the involvement of inflammatory markers/ adipokines and lipids in the development of obesity co-morbidities. She has used different strategies to study the complex molecular basis of metabolic disorders including adipokine profiling, whole genome gene expression profiling, genome-wide association studies, proteomics, and whole exome sequencing (WES). She has authored, and co-authored numerous research manuscripts and I has recently developed interest in a subtype of obesity: the metabolically healthy obesity (MHO) and microbiome in health and diseases.
Publications
Selected Publications
Doumatey AP, He WJ, Gaye A, et al. Circulating MiR-374a-5p is a potential modulator of the inflammatory process in obesity. Sci Rep. 2018 May 16;8(1):7680. doi: 10.1038/s41598-018-26065-5.
Gaye A, Doumatey AP*, Davis SK, Rotimi CN, Gibbons GH. Whole-genome transcriptomic insights into protective molecular mechanisms in metabolically healthy obese African Americans. NPJ Genom Med. 2018 Jan 29; 3:4. doi: 10.1038/s41525-018-0043-x. eCollection 2018. PubMed PMID: 29387454; PubMed Central PMCID: PMC5789085. (* co-first-author)
Rotimi CN, Bentley AR, Doumatey AP, Chen G, Shriner D, Adeyemo A. The genomic landscape of African populations in health and disease. Hum Mol Genet. 2017 Oct 1;26(R2): R225-R236. doi: 10.1093/hmg/ddx253
Chen G, Doumatey AP*, Zhou J, Lei L, Bentley AR, Tekola-Ayele F, Adebamowo SN, Baker JL, Fasanmade O, Okafor G, et al. Genome-wide analysis identifies an african-specific variant in SEMA4D associated with body mass index. Obesity (Silver Spring). 2017 Apr;25(4):794-800. doi: 10.1002/oby.21804. Epub 2017 Mar 13. PubMed PMID: 28296344; PubMed Central PMCID: PMC5373947 (* co-first author)
Böger CA, Gorski M, McMahon GM, Xu H, Chang YC, van der Most PJ, Navis G, Nolte IM, de Borst MH, Zhang W, et al. NFAT5 and SLC4A10 Loci Associate with Plasma Osmolality. J Am Soc Nephrol. 2017 Mar 30. pii: ASN.2016080892. doi: 10.1681/ASN.2016080892. [Epub ahead of print] PubMed PMID: 28360221.
Adebamowo SN, Adeyemo AA, Tekola-Ayele F, Doumatey AP, et al. Impact of Type 2 Diabetes on Impaired Kidney Function in Sub-Saharan African Populations. Front Endocrinol (Lausanne). 2016 May. PubMed PMID: 27303364; PubMed Central, PMCID: PMC4884893.
Doumatey AP, Zhou J, Zhou M, Prieto D, Rotimi CN, Adeyemo A. Proinflammatory and lipid biomarkers mediate metabolically healthy obesity: A proteomics study. Obesity (Silver Spring). 2016 Jun; 24(6):1257-65. PubMed PMID: 27106679; PubMed Central PMCID: PMC4882259.
Adeyemo AA, Tekola-Ayele F, Doumatey AP, Bentley AR, et al. Evaluation of Genome Wide Association Study Associated Type 2 Diabetes Susceptibility Loci in Sub Saharan Africans. Front Genet. 2015 Nov 24; 6:335. PubMed PMID: 26635871; PubMed Central PMCID: PMC4656823.
Tekola-Ayele F, Doumatey AP, Shriner D, Bentley AR, et al. Genome-wide association study identifies African-ancestry specific variants for metabolic syndrome. Mol Genet Metab. 2015 Dec; 116(4):305-13. PubMed PMID: 26507551.
Doumatey AP, Xu H, Huang H, Trivedi NS, et al. Global Gene Expression Profiling in Omental Adipose Tissue of Morbidly Obese Diabetic African Americans. J Endocrinol Metab. 2015 Jun; 5(3):199-210. PubMed PMID: 26504501; PubMed Central PMCID: PMC4618674.
Doumatey AP, Bentley AR, Zhou J, Huang H, et al. Paradoxical Hyperadiponectinemia is Associated with the Metabolically Healthy Obese (MHO) Phenotype in African Americans. J Endocrinol Metab. 2012 Apr 1; 2(2):51-65. PubMed PMID: 23293696; PubMed Central PMCID: PMC3534968.
Chen G, Bentley A, Adeyemo A, Shriner D, Zhou J, Doumatey A, et al. Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans. Hum Mol Genet. 2012 Oct 15; 21(20):4530-6. PubMed PMID: 22791750; PubMed Central PMCID: PMC3459464.
Doumatey AP, Chen G, Tekola Ayele F, Zhou J, et al. C-reactive protein (CRP) promoter polymorphisms influence circulating CRP levels in a genome-wide association study of African Americans. Hum Mol Genet. 2012 Jul 1; 21(13):3063-72. PubMed PMID: 22492993; PubMed Central PMCID: PMC3373247.
Charles BA, Doumatey A, Huang H, Zhou J, et al. The roles of IL-6, IL-10, and IL-1RA in obesity and insulin resistance in African-Americans. J Clin Endocrinol Metab. 2011 Dec; 96(12). PubMed PMID: 21956416; PubMed Central PMCID: PMC3232609.
Ramos E, Chen G, Shriner D, Doumatey A, et al. Replication of genome-wide association studies (GWAS) loci for fasting plasma glucose in African Americans. Diabetologia. 2011 Apr; 54(4):783-8. PubMed PMID: 21188353; PubMed Central PMCID: PMC3052446.
Sumner AE, Zhou J, Doumatey A, Imoisili OE, et al. Low HDL-Cholesterol with Normal Triglyceride Levels is the Most Common Lipid Pattern in West Africans and African Americans with Metabolic Syndrome: Implications for Cardiovascular Disease Prevention. CVD Prev Control. 2010 Sep 1; 5(3):75-80. PubMed PMID: 21113431; PubMed Central PMCID:PMC2989612.
Doumatey AP, Lashley KS, Huang H, Zhou J, et al. Relationships among obesity, inflammation, and insulin resistance in African Americans and West Africans. Obesity (Silver Spring). 2010 Mar; 18(3):598-603. PubMed PMID: 19798069; PubMed Central PMCID: PMC4151268.
Collaborative Publications
Gourh P, Remmers EF, Boyden SE, Alexander T, Morgan ND, Shah AA, Mayes MD, Doumatey A et al. Whole-Exome Sequencing to Identify Rare Variants and Gene Networks that Increase Susceptibility to Scleroderma in African Americans. Arthritis Rheumatol. 2018 May 6. doi: 10.1002/art.40541
Pattaro C…, Doumatey A, et al. Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nat Commun. 2016 Jan 21;7: 10023. PubMed PMID: 26831199; PubMed Central PMCID: PMC4735748.
Locke AE…, Doumatey A, et al. Genetic studies of body mass index yield new insights for obesity biology. Nature 2015 Feb 12; 518(7538):197-206. PMID: 25673413
Shungin D…, Doumatey A et al. New genetic loci link adipose and insulin biology to body fat distribution. Nature 2015 Feb 12; 518(7538):187-96. doi: 10.1038/nature14132. PMID: 25673412
Ng MC …, Doumatey A, et al. Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes. PLoS Genet. 2014 Aug 7; 10(8):e1004517.eCollection 2014 Aug. (Collaborative study with several consortia)
Steinthorsdottir V…, Doumatey A et al. A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet. 2007 Jun; 39(6):770-5. Epub 2007 Apr 26. PubMed PMID: 17460697.
Helgason A., Doumatey A, et al. Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet. 2007 Feb; 39(2):218-25. Epub 2007 Jan 7. PubMed PMID: 17206141.
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Publications
Selected Publications
Doumatey AP, He WJ, Gaye A, et al. Circulating MiR-374a-5p is a potential modulator of the inflammatory process in obesity. Sci Rep. 2018 May 16;8(1):7680. doi: 10.1038/s41598-018-26065-5.
Gaye A, Doumatey AP*, Davis SK, Rotimi CN, Gibbons GH. Whole-genome transcriptomic insights into protective molecular mechanisms in metabolically healthy obese African Americans. NPJ Genom Med. 2018 Jan 29; 3:4. doi: 10.1038/s41525-018-0043-x. eCollection 2018. PubMed PMID: 29387454; PubMed Central PMCID: PMC5789085. (* co-first-author)
Rotimi CN, Bentley AR, Doumatey AP, Chen G, Shriner D, Adeyemo A. The genomic landscape of African populations in health and disease. Hum Mol Genet. 2017 Oct 1;26(R2): R225-R236. doi: 10.1093/hmg/ddx253
Chen G, Doumatey AP*, Zhou J, Lei L, Bentley AR, Tekola-Ayele F, Adebamowo SN, Baker JL, Fasanmade O, Okafor G, et al. Genome-wide analysis identifies an african-specific variant in SEMA4D associated with body mass index. Obesity (Silver Spring). 2017 Apr;25(4):794-800. doi: 10.1002/oby.21804. Epub 2017 Mar 13. PubMed PMID: 28296344; PubMed Central PMCID: PMC5373947 (* co-first author)
Böger CA, Gorski M, McMahon GM, Xu H, Chang YC, van der Most PJ, Navis G, Nolte IM, de Borst MH, Zhang W, et al. NFAT5 and SLC4A10 Loci Associate with Plasma Osmolality. J Am Soc Nephrol. 2017 Mar 30. pii: ASN.2016080892. doi: 10.1681/ASN.2016080892. [Epub ahead of print] PubMed PMID: 28360221.
Adebamowo SN, Adeyemo AA, Tekola-Ayele F, Doumatey AP, et al. Impact of Type 2 Diabetes on Impaired Kidney Function in Sub-Saharan African Populations. Front Endocrinol (Lausanne). 2016 May. PubMed PMID: 27303364; PubMed Central, PMCID: PMC4884893.
Doumatey AP, Zhou J, Zhou M, Prieto D, Rotimi CN, Adeyemo A. Proinflammatory and lipid biomarkers mediate metabolically healthy obesity: A proteomics study. Obesity (Silver Spring). 2016 Jun; 24(6):1257-65. PubMed PMID: 27106679; PubMed Central PMCID: PMC4882259.
Adeyemo AA, Tekola-Ayele F, Doumatey AP, Bentley AR, et al. Evaluation of Genome Wide Association Study Associated Type 2 Diabetes Susceptibility Loci in Sub Saharan Africans. Front Genet. 2015 Nov 24; 6:335. PubMed PMID: 26635871; PubMed Central PMCID: PMC4656823.
Tekola-Ayele F, Doumatey AP, Shriner D, Bentley AR, et al. Genome-wide association study identifies African-ancestry specific variants for metabolic syndrome. Mol Genet Metab. 2015 Dec; 116(4):305-13. PubMed PMID: 26507551.
Doumatey AP, Xu H, Huang H, Trivedi NS, et al. Global Gene Expression Profiling in Omental Adipose Tissue of Morbidly Obese Diabetic African Americans. J Endocrinol Metab. 2015 Jun; 5(3):199-210. PubMed PMID: 26504501; PubMed Central PMCID: PMC4618674.
Doumatey AP, Bentley AR, Zhou J, Huang H, et al. Paradoxical Hyperadiponectinemia is Associated with the Metabolically Healthy Obese (MHO) Phenotype in African Americans. J Endocrinol Metab. 2012 Apr 1; 2(2):51-65. PubMed PMID: 23293696; PubMed Central PMCID: PMC3534968.
Chen G, Bentley A, Adeyemo A, Shriner D, Zhou J, Doumatey A, et al. Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans. Hum Mol Genet. 2012 Oct 15; 21(20):4530-6. PubMed PMID: 22791750; PubMed Central PMCID: PMC3459464.
Doumatey AP, Chen G, Tekola Ayele F, Zhou J, et al. C-reactive protein (CRP) promoter polymorphisms influence circulating CRP levels in a genome-wide association study of African Americans. Hum Mol Genet. 2012 Jul 1; 21(13):3063-72. PubMed PMID: 22492993; PubMed Central PMCID: PMC3373247.
Charles BA, Doumatey A, Huang H, Zhou J, et al. The roles of IL-6, IL-10, and IL-1RA in obesity and insulin resistance in African-Americans. J Clin Endocrinol Metab. 2011 Dec; 96(12). PubMed PMID: 21956416; PubMed Central PMCID: PMC3232609.
Ramos E, Chen G, Shriner D, Doumatey A, et al. Replication of genome-wide association studies (GWAS) loci for fasting plasma glucose in African Americans. Diabetologia. 2011 Apr; 54(4):783-8. PubMed PMID: 21188353; PubMed Central PMCID: PMC3052446.
Sumner AE, Zhou J, Doumatey A, Imoisili OE, et al. Low HDL-Cholesterol with Normal Triglyceride Levels is the Most Common Lipid Pattern in West Africans and African Americans with Metabolic Syndrome: Implications for Cardiovascular Disease Prevention. CVD Prev Control. 2010 Sep 1; 5(3):75-80. PubMed PMID: 21113431; PubMed Central PMCID:PMC2989612.
Doumatey AP, Lashley KS, Huang H, Zhou J, et al. Relationships among obesity, inflammation, and insulin resistance in African Americans and West Africans. Obesity (Silver Spring). 2010 Mar; 18(3):598-603. PubMed PMID: 19798069; PubMed Central PMCID: PMC4151268.
Collaborative Publications
Gourh P, Remmers EF, Boyden SE, Alexander T, Morgan ND, Shah AA, Mayes MD, Doumatey A et al. Whole-Exome Sequencing to Identify Rare Variants and Gene Networks that Increase Susceptibility to Scleroderma in African Americans. Arthritis Rheumatol. 2018 May 6. doi: 10.1002/art.40541
Pattaro C…, Doumatey A, et al. Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nat Commun. 2016 Jan 21;7: 10023. PubMed PMID: 26831199; PubMed Central PMCID: PMC4735748.
Locke AE…, Doumatey A, et al. Genetic studies of body mass index yield new insights for obesity biology. Nature 2015 Feb 12; 518(7538):197-206. PMID: 25673413
Shungin D…, Doumatey A et al. New genetic loci link adipose and insulin biology to body fat distribution. Nature 2015 Feb 12; 518(7538):187-96. doi: 10.1038/nature14132. PMID: 25673412
Ng MC …, Doumatey A, et al. Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes. PLoS Genet. 2014 Aug 7; 10(8):e1004517.eCollection 2014 Aug. (Collaborative study with several consortia)
Steinthorsdottir V…, Doumatey A et al. A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet. 2007 Jun; 39(6):770-5. Epub 2007 Apr 26. PubMed PMID: 17460697.
Helgason A., Doumatey A, et al. Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet. 2007 Feb; 39(2):218-25. Epub 2007 Jan 7. PubMed PMID: 17206141.
Last updated: April 10, 2024